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Building support

Gov. Glenn Youngkin made headlines last December when he announced a $90 million-plus pitch to launch “Virginia’s Research Triangle.”

Initially envisioned as a cooperative initiative among Virginia Commonwealth University, Virginia Tech and the University of Virginia, the triangle was expanded into more of a rhombus following the addition of Old Dominion University to the research network during the 2024 General Assembly session.

If approved by the legislature and Youngkin, a total of $96.4 million would be divided among the four public research universities: $46.5 million for U.Va.’s Paul and Diane Manning Institute of Biotechnology; $31 million for Virginia Tech’s Roanoke-based Fralin Biomedical Research Institute at VTC; $14.9 million for VCU’s Medicines for All Institute; and $4 million for ODU, which a university spokesperson says plans to develop its “digital patient model,” a “simulation-based environment” for virtually testing treatments and therapies. (As of this story’s press deadline, the budget was still in negotiations.)

This would help establish a biotechnology, life sciences and pharmaceutical manufacturing network in Virginia, partnering research universities with the Virginia Innovation Partnership Authority to collaborate on commercialization and startup support.

It’s also hoped that the statewide research network will help spur the creation and expansion of Virginia businesses as well as attract outside companies to locate here. This endeavor comes on the heels of several developments at each hub of the proposed research network.

In December 2023, U.Va. broke ground on the $350 million Manning biotech institute. Expected to open in late 2026, it received a $100 million gift in January 2023 from its namesakes, Charlottesville-based PBM Capital Chairman and CEO Paul Manning and his wife, Diane.

In October 2023, the Richmond-Petersburg region was selected as one of 31 federally designated tech hubs, allowing the region to compete for up to $70 million in federal grants as it focuses on strengthening advanced pharmaceutical manufacturing.

And in September 2023, Roanoke’s Fralin Institute announced it had received a $50 million commitment to support cancer and neuroscience research from a foundation established by the estate of Richmond philanthropist Bill Goodwin’s late son, Hunter.

Frank Gupton, CEO of the Medicines for All Institute at VCU, and a co-founder of Richmond-based pharmaceutical company Phlow, compares Youngkin’s proposal to North Carolina’s Research Triangle — “except we’re doing more translational work, as opposed to basic science.

“If U.Va., Virginia Tech or VCU comes up with a new innovative drug, we’ll have a platform that we’ll be able to scale up and do the clinical trials for. It’s going to be an end-to-end capability,” Gupton says. “My hope is that we’ll be working together and leveraging our collective resources to be able to do some really meaningful research and development that will benefit all the universities.”

Joe Benevento, CEO and president of Virginia Innovation Partnership Corp., VIPA’s nonprofit operations arm, and formerly Virginia’s deputy secretary of commerce and trade, says the commonwealth’s proposed research network will attract startups seeking access to research facilities, wet labs, testing space and equipment.

“Startups really can have the opportunity to collaborate and partner with world-class university researcher talent [and] build off and leverage that IP and know-how to accelerate commercial development, attract growth investment and enhance market delivery,” Benevento says.

High tech, high wages

Erin Burcham, president of Verge, an umbrella organization for the Roanoke-Blacksburg Technology Council and Roanoke’s Regional Accelerator and Mentoring Program (RAMP), says that additional biotech research funding will increase opportunities for biotech companies, growing the state’s economy.

“Biotech in our region is transforming the economy in a really impactful way,” says Burcham. “We’re going from a very industrial town that was really focused on Norfolk Southern and trains to more of an innovation economy where we’re focused on high-wage, high-tech, advanced science-type companies.”

Paul Manning sees the capacity for collaboration between the research network’s hubs. While VCU will continue focusing on large-scale pharma manufacturing, U.Va. and Virginia Tech will use the new state funding to move research from labs to patient treatments. Charlottesville Economic Development Director Chris Engel has said that the Manning institute alone could support a bioscience cluster of about 75 companies and 3,000 employees.

“There’s so much to be done, and we are in a revolution in biotechnology right now. There won’t be much overlap [between hubs], and I think the research that’s going to be done at every institution will help all,” says Manning, adding that the quality of research facilities will motivate “people and companies … [to] start moving here to set up their operations in Virginia because we have such a deep bench of scientists that will be able to provide support.”

Dr. K. Craig Kent, CEO of UVA Health and executive vice president for health affairs at U.Va., also thinks startups will be drawn to the research network.

“Biomanufacturing is really expensive. It costs a lot of money to develop these facilities,” Kent says. “Part of the draw is that smaller companies trying to get into phase 1 drug trials don’t have the money to build their own facilities. The research triangle could partner with these companies and grant access to their facilities.”

Kent says this initiative will attract companies outside Virginia while retaining existing biotech startups.

“As long as we have the ability to help those companies translate and run clinical trials, they’ll stay here in Virginia,” Kent says. “If we have a critical mass of intellect, researchers that do this kind of work, companies want to associate with those individuals. They want to be around them. They want to partner with them in their own research.”

He compares the draw that Virginia’s research network will have to that of Boston, which attracts startups and researchers to its large number of top-level universities and biotech companies with an associated talent pool. But Virginia, he says, can offer researchers a much lower cost of living and higher quality of life.

Marc Nelson, Roanoke’s economic development director, says he’s already seen a transformational change in his city from the Fralin Biomedical Research Institute at VTC, which was founded in 2010 by Virginia Tech and Carilion Clinic.

The institute “really helps from an economic development standpoint … [to] create really lucrative and innovative jobs,” Nelson says. “We’re just getting started, and Fralin Biomedical and Carilion have really led the way. Now you’re seeing the partners come up behind them and give them the support structure they need.”

And the research network isn’t the only new proposed state initiative that could help spur the creation of biotech startups. In collaboration with Richmond-based innovation incubator Activation Capital and CvilleBioHub, a nonprofit that works to boost Charlottesville-area biotech businesses, Verge has applied for a GO Virginia grant that would total roughly $15 million. The funding would support health care innovations at an earlier stage in the creation process.

“These three organizations are very passionate about identifying additional capital through grants and public-private funding to support the growing, commercialized biotech side of the state, and doing it hand-in-hand with the universities so we can nurture intellectual property,” says Burcham of Verge. “Entrepreneurial organizations are responding to the money coming in for biotech research and really trying to build out a holistic ecosystem for those startups to thrive in Virginia.” 

Gov. proposes $90M to launch ‘Va. Research Triangle’

In a preview of his 2024-26 proposed budget, Gov. Glenn Youngkin announced Monday that he is including $90 million in one-time funds to create “Virginia’s Research Triangle,” a network between the University of Virginia, Virginia Commonwealth University and Virginia Tech to build collaboration in biotechnology, life sciences and pharmaceutical manufacturing.

Youngkin’s biennial budget plan will include $50 million for U.Va.’s Manning Institute for Biotechnology, $27 million for Virginia Tech’s Fralin Biomedical Research Institute at VTC and $13 million for VCU’s Medicines for All Institute, according to the announcement. The three institutions must first sign a memorandum of understanding with the Virginia Innovation Partnership Authority and each other before receiving the money.

Youngkin plans to unveil his budget proposal Dec. 20, and the Virginia General Assembly will take up the plan and make its own adjustments next year, before returning the budget to the governor for his signature. The General Assembly’s 2024 regular session starts Jan. 10, 2024, although typically lawmakers call a special session in the spring to finalize the budget.

“Today’s investment announcement lays the groundwork for remarkable startup innovation and commercialization that interconnects Charlottesville, the greater Richmond area, Roanoke and the New River Valley. Through this state commitment and private philanthropy, we are building Virginia’s research triangle and network, supporting our higher education institutions’ research endeavors, and expanding Virginia’s university research capacity that will enhance life-saving research development for generations to come,” Youngkin said in a statement. “My administration is committed to building Virginia’s research engine for the future and creating high-paying jobs in the process.”

The governor’s announcement comes shortly after the groundbreaking ceremony for the $350 million Manning Institute in Charlottesville, in which the state already invested $50 million, along with $150 million from U.Va. and $100 million from donors Paul and Diane Manning, who made the donation in January. Dr. Craig Kent, CEO of UVA Health, said in January the institute could help Virginia compete with other U.S. biotech hubs, including North Carolina’s Research Triangle.

VCU’s Medicines for All Institute is already a key part of Petersburg’s pharmaceutical industry hub, which has received federal funding to manufacture more medications domestically. Drug manufacturers started moving production abroad decades ago, leading to national security concerns and supply chain issues in recent years.

In Roanoke, the Fralin Institute is the home of biomedical research scientists in different fields; in September, a foundation established by the estate of Richmond philanthropist Bill Goodwin’s late son, Hunter, gave the institute $50 million to support cancer and neuroscience research.

Youngkin said in his announcement that VIPA will help bring the three institutes’ biotech innovations to market faster and will provide startup support.

“Innovation is at the heart of a thriving economy and the commonwealth of Virginia,” VIPA President Joseph Benevento said in a statement. “Today’s landmark investment announced by Gov. Youngkin will help accelerate university collaboration and elevate Virginia’s leadership in the critical biotech, life sciences and pharmaceutical manufacturing health sectors.”

Civica announces plans for $27.8M lab in Chesterfield

Nonprofit drugmaker Civica Rx is investing $27.8 million to establish a new 55,000-square-foot laboratory in Chesterfield County’s Meadowville Technology Park, Gov. Glenn Youngkin announced Thursday.

The expansion will add 51 jobs, according to a news release. The company will also host a scale-up manufacturing facility run by Virginia Commonwealth University’s Medicines for All Institute, which will add more jobs.

The generic drug maker is currently building a 140,000-square-foot, $124.5 million manufacturing facility in Petersburg that will become the Utah-based company’s North American headquarters when it opens in 2024. The Chesterfield lab will support that factory through testing and development of new products.

“Civica’s investment is another transformational step forward in strengthening the advanced pharmaceutical manufacturing hub in the Richmond-Petersburg region and positioning Virginia as a key player in domestic drug manufacturing in America,” Youngkin said in a statement. “Civica is a critical partner in the commonwealth’s emerging pharmaceutical ecosystem that will ensure access to affordable, lifesaving medications while providing high-quality jobs and an incredible boost to our economy.”

Construction of the lab is being funded through a $52.9 million grant from the U.S. Economic Development Administration to the Alliance for Building Better Medicine, Youngkin’s office said. Civica is providing matching capital. The alliance is a coalition of industry and public organizations from the Richmond and Petersburg regions that aim to advance and scale up the manufacturing of affordable, essential medicines in the United States. It includes Civica, Richmond-based Phlow Corp., VCU and Virginia State University.

In April, Civica said that its new factory will include space for insulin manufacturing after donors expressed concern over the cost of insulin. Civica plans to produce three forms of insulin priced at $30 per vial. The sweeping Inflation Reduction Act places a $35 monthly cap on insulin prices for Medicare patients, but a measure that would have extended that cap to all insured Americans was blocked by Senate Republicans.

“With this investment, Civica is building on its long-term commitment to patients — and to Virginia,” Civica President and CEO Ned McCoy said in a statement. “This lab will support a skilled and highly trained workforce who will ensure Civica’s affordable insulin, as well as other essential medicines, meet the highest standards.”

The lab testing facility is expected to open soon after the Petersburg plant.

The Virginia Economic Development Partnership worked with Chesterfield County to secure the project and Youngkin approved a $400,000 grant to the county for assistance. The Virginia Talent Accelerator Program will help with recruitment and training for the new jobs. In addition, Chester-based Brightpoint Community College has created a training program to help people gain qualifications for manufacturing technician jobs at the upcoming Civica Petersburg plant, Youngkin said.