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A ‘North Star’ for others

It’s been a few months since Virginia Commonwealth University’s Massey Comprehensive Cancer Center was added to an elite, national list of comprehensive cancer centers, but the excitement around the June announcement continues.

“It definitely is a huge deal,” says the center’s director, Dr. Robert A. Winn. “This is something we’ve chased for the better part of several decades.” Winn joined Massey as its director in 2019, but he’s well-versed on the history behind VCU’s quest to gain the comprehensive designation for Massey from the National Cancer Institute.

In fact, Winn found it “surprising and puzzling” that Virginia had no NCI comprehensive cancer centers when he came to VCU from Illinois, which has two comprehensive cancer centers, both in Chicago. Nearby states North Carolina, Maryland, Pennsylvania and Tennessee all have multiple NCI-designated comprehensive cancer centers.

“We can now join the ranks of those states,” Winn says, noting that the University of Virginia Cancer Center became the first to receive comprehensive cancer center status in February 2022, followed by Massey in June.

U.Va. and Massey were previously on the NCI’s list of designated cancer centers, which means they met the rigorous requirements to be funded by NCI to deliver cutting-edge treatments. Comprehensive status is another step up, and it’s considered the gold star for cancer institutions. It denotes superior work in the areas of research, training and community impact. Currently, there are 72 NCI-designated cancer centers in the country. Of those, 54 are comprehensive cancer centers.

Being in the comprehensive category gives Massey a tremendous boost in terms of resources and visibility, enabling it to “offer care at a level that wasn’t there before,” Winn says. “It’s not only a big deal for Massey, it’s a big deal for the commonwealth.”

Community-to-bench model

A key to gaining comprehensive status, according to Winn and others at VCU, is Massey’s dedication to serving Virginians who previously may have been underserved when it came to advanced cancer treatments. The concept of equitable care is at the forefront of VCU administration goals, Winn says, and Massey is emerging as a national model for how to approach cancer research and treatment by looking first at the needs of the patient base.

This “community-to-bench” model calls for community involvement to shape the research done at the laboratory bench and then guide the design and implementation of clinical trials and treatment programs. “It’s looking at who we serve and making sure the science serves them,” he says. Massey generally draws patients from Central, Eastern and Southern Virginia.

“Innovation does not equal impact for all people,” Winn says, so Massey is stepping out of the traditional mold for how to provide top-level care. It’s making a concerted effort to involve and help “invisible communities” that may not get much attention at other cancer centers, he says.

This approach is in line with the mission of VCU Health, says the health system’s interim CEO, Dr. Marlon Levy. “We’re a high-tech, high-touch hospital,” he says. “But we’re also a safety-net hospital whose doors are open to all.”

Achieving comprehensive status is “really the pinnacle of many, many years of effort by a very large team,” Levy says, adding that Winn’s push for increased community involvement put Massey “over the top.”

Massey follows a path different from many of its peers on the NCI comprehensive list.

“The hallmark of this comprehensive cancer center … is we’re serving a very vulnerable population,” Levy says. “A lot of other cancer centers may not focus on that the way Massey does.” In Levy’s opinion, this is just the beginning of what Massey can do to better serve all patients: “We aspire to transform cancer care delivery … and care access to the patients we serve.”

Dr. Paula Fracasso, Massey’s deputy director, is confident the cancer center will be recertified by the NCI as a comprehensive center in 2028. Photo courtesy VCU Massey Comprehensive Cancer Center

Nearly 50-year history

Massey’s roots reach back to 1974, when VCU established a cancer center on the Medical College of Virginia campus. In 1983, it was named Massey Cancer Center in honor of a gift from coal-magnate brothers Bill and E. Morgan Massey. Under the direction of Dr. Gordon Ginder, who became the cancer center’s director in 1997, Massey experienced steady growth and added advanced research labs. Ginder led Massey for more than 20 years before announcing his decision to step down in 2019.

Massey made a national name for itself in bone marrow transplants and stem cell research, Levy says. And the comprehensive designation puts Massey in an even better position to “attract top talent … to do more advanced research,” he says. Today, the center has about 150 researchers across nearly 40 academic departments at VCU.

While downtown Richmond still is the nucleus for Massey operations, its patients receive oncology care in locations throughout the Richmond metropolitan area as well as in smaller communities elsewhere in the state, including Tappahannock and South Hill. Securing expansion space in downtown Richmond is difficult due to space constraints. VCU Health made headlines this year for backing out of a multimillion-dollar private development deal for a medical office tower at the site of the city’s former Public Safety Building, located near VCU hospital buildings. VCU paid $73 million to exit that deal, which could have cost as much as $650 million over 25 years. In June, VCU received city approval to raze the Public Safety Building, and it may instead build a new $415 million dental school there.

Most NCI-designated comprehensive cancer centers are affiliated with universities, many of which are large, public schools. Examples include Ohio State University, the University of Texas at Austin, the University of Alabama and the University of Michigan. Others with comprehensive status are affiliated with widely recognized private schools such as Duke University and Johns Hopkins University.

‘In the Ivy Leagues’

Winn joined Massey as its director and Lipman chair of oncology after serving as director of the University of Illinois Cancer Center in Chicago, which is not NCI-designated but is known for its community focus in developing and executing treatment plans. Winn brought with him a reputation for advancements in treating lung cancer as well as his work to eliminate health disparities. He has continued to draw national attention as a champion of equitable care. In 2021, he was the first recipient of the Association of American Cancer Institutes’ Cancer Health Equity Award. He is also the namesake of the Robert A. Winn Diversity in Clinical Trials Award Program, a $114 million training and education program for clinical trialists that VCU is spearheading in partnership with the Bristol Myers Squibb Foundation.

Anita Harrison, Massey’s executive director of research strategy, says Winn’s community-focused programs have propelled Massey forward. “We are involving the community in everything we do,” Harrison says. Massey is even working with high school science programs to cultivate future employees across diverse backgrounds. But the community focus alone would not have gained Massey its NCI-designated comprehensive status.

When applying for the NCI designation, “you’re laying out the case as to why your institution is leading the nation in cancer research,” Harrison explains. In addition to proving that the institution is breaking new ground in a meaningful way, “you have to show that you’re training the next generation … and actually making an impact in your immediate community.”

The work doesn’t stop now that Massey has received the comprehensive designation. “We cannot let up at all,” Harrison says. “We have to show that we’re making more impact … especially through clinical trials.”

And, in keeping with VCU’s mission, treatments must be available to everyone. “All the discoveries are worthless unless we can get them to the people who need them,” she says, adding that Massey needs to aim to “improve outcomes for all people.”

In the big picture, Massey is significantly smaller than many of the institutions on the comprehensive list in terms of patient volume and area population. “We’re not in New York City,” Harrison says. While Massey has about 150 researchers, other comprehensive centers might have 500. “Even though we’re small, we’re mighty,” she says. “We’ve really kind of made our mark, especially in this health equity area.”

Massey may not have the household name recognition of Memorial Sloan Kettering Cancer Center in New York or the University of Texas MD Anderson Cancer Center, but it now has achieved the same NCI status. That’s an accomplishment for which Massey should be proud, Harrison says: “We’re up there in the Ivy Leagues of cancer centers.”

Vision for the future

Dr. Paula M. Fracasso, formerly of the University of Virginia, joined Massey last year as deputy director and senior vice president of the cancer service line. An oncologist, medical school professor and former pharmaceutical executive, Fracasso works with Winn on Massey’s initiatives while coordinating the service line that helps patients navigate their health care.

“I have the incredible opportunity to … work with all to ensure we deliver the highest quality care through the entire patient journey,” Fracasso says. She taps into resources offered by the American Cancer Society and other philanthropic and stakeholder organizations to “help people who need help.” That may involve anything from explaining treatment options to lining up transportation and lodging.

Massey’s advancements in bone marrow transplants and stem cell research draw patients from throughout the state and beyond. “We are the only [Virginia] site that has MRI-guided radiation therapy,” Fracasso says. The center also offers some less technical programs, such as its Survivorship Clinic, which helps cancer patients thrive during and after treatment.

Fracasso feels sure that Massey will retain its comprehensive status when its NCI recertification rolls around in five years. “We’re going to continue doing what we did to earn it,” she says. “We are extremely thrilled, excited, jazzed … to let the people of the commonwealth of Virginia know what kind of care we give and will continue to be giving.”

She describes this as an “incredibly exciting time” in the history of Massey. The center will continue to strive for a “seamless patient journey with state-of-the-art care,” Fracasso says. “That’s what we’re trying to do at Massey every day for every patient and every family.”

Philanthropic support has been critical to Massey’s successes thus far, Winn says, and will continue to play a big role in its future. He would like to see an expansion in the center’s wet laboratory space and data sciences research. “Right now, the shirt is tight-fitting,” he says. More research space would be welcomed. “The complexity of cancer care is incredible,” he says.

Winn also dreams of a day that Massey has its own hospital, with its own emergency room, just for cancer patients. But for now, he’s happy to be at the helm of a comprehensive cancer center that conducts research involving and serving people who might otherwise not get the care they need. In this way, he says, Massey is a “North Star for many other cancer centers.” 


VCU at a glance

Founded

Virginia Commonwealth University was founded in 1838 as the Medical College of Hampden-Sydney and was later renamed the Medical College of Virginia. In 1968, MCV merged with Richmond Professional Institute to form VCU.

Campus

VCU has two campuses in downtown Richmond covering a total of 198 acres. The Monroe Park Campus houses most undergraduate students and classes. VCU’s five health sciences schools, the College of Health Professions, VCU Massey Comprehensive Cancer Center and VCU Health are located on the MCV campus.

Enrollment

Undergraduate: 21,270

Graduate: 5,622

First professional: 1,516

International: 999

In-state: 86%

Minority: 47%

Employees
24,065*

Faculty

Full-time faculty: 2,501

Full-time university and academic professionals: 3,390

Tuition and fees

In-state tuition and fees: $16,233

Tuition and fees (out of state): $38,817

Room and board and other fees: $13,283

Average financial aid awarded to full-time freshmen seeking assistance: $19,290

About VCU Massey Comprehensive Cancer Center

More than 1,000 people work at Massey, which sees more than 3,000 new patients every year. Massey patients receive care at multiple locations, including:

VCU Health’s Adult Outpatient Pavilion

VCU Medical Center

VCU Health Stony Point Campus

VCU Health Community Memorial Hospital in South Hill

VCU Health Tappahannock Hospital

* Includes VCU and VCU Health

Massey Center, VCU Health hire cancer exec

Virginia Commonwealth University Massey Cancer Center and VCU Health announced Tuesday that Dr. Paula M. Fracasso, formerly of the University of Virginia, is now the cancer center’s deputy director and senior vice president of the health system’s cancer service line.

An oncologist, former pharmaceutical executive and medical school professor, Fracasso joined VCU and the Massey Center this month. Fracasso will work with leadership at Massey, VCU Health and the VCU School of Medicine to coordinate patient care, education and research initiatives concerning cancer.

“I’m excited to be joining such a strong, accomplished team of clinicians, researchers and staff all motivated by our shared mission to reduce the cancer burden for all Virginians,” Fracasso said in a statement.

“Dr. Fracasso’s deep expertise across the spectrum of patient care and clinical and translation research in [National Cancer Institute]-designated cancer centers will greatly contribute to our continued efforts to enhance patient care by streamlining operations under a centralized cancer service line,” VCU Medical Center President Michael Roussos said in a statement.

Fracasso, who served as professor of women’s oncology research as well as deputy director of U.Va.’s cancer center, previously worked at Washington University in St. Louis, Bristol-Myers Squibb Co. and Adaptimmune Therapeutics PLC. At Washington University in St. Louis, she built the Siteman Cancer Center’s Developmental Therapeutics program for phase 1 and 2 clinical trials. She is also a member of the NCI’s operational efficiency working group, which aims to speed up the pace of clinical trials.

Fracasso holds an undergraduate degree from the College of the Holy Cross and medical and graduate degrees from Yale University. She completed her internal medicine internship and residency at Beth Israel Hospital in Boston, her postdoctoral research fellowship at the Massachusetts Institute of Technology and her clinical fellowship in hematology-oncology at Tufts Medical Center.

VCU Massey Center names internship for attorney

Virginia Commonwealth University’s Massey Cancer Center has established an internship named for Hunton Andrews Kurth LLP Partner Rudene Mercer Haynes, the law firm announced last week.

“I am humbled by this honor and pledge to continue my support of the live-saving and life-changing work performed by the brilliant clinicians and researchers at VCU Massey Cancer Center every day,” Haynes said in a statement.

In the Rudene Mercer Haynes Clinical Trials Office Summer Internship, interns are meant to develop an appreciation for the role academic medicine has in cancer research and the impact of research on cancer disparities.

The six-week internship will support rising third-years, fourth-years or prospective 2022 graduates interested in learning about clinical research. Interns will receive a $2,820 stipend based on 30 hours of commitments per week.

Haynes is a hiring partner of Hunton Andrews Kurth and serves on the Goals and Metrics Subcommittee of the firm’s Diversity and Inclusion Committee. In 2021, Haynes was one of The National Black Lawyers’ Top 100 lawyers. Haynes was also a recipient of the Virginia Business Women in Leadership Award in 2021.

She was part of the trio that created “Facts & Faith Fridays,” a series of weekly calls with the Black faith community to provide information on COVID-19, transmission, vaccination and improving outcomes. Both Dr. Anthony Fauci and first lady Jill Biden have joined the discussions.

In 2021, Haynes received the Humanitarian Award from the Richmond chapter of Virginia Center for Inclusive Communities. Additionally, she has served on the advisory board of the Massey Center since July 2020.

“Rudene Mercer Haynes embodies the spirit of service that VCU Massey Cancer holds as one of its guiding principles,” Tremayne D. Robertson, Massey’s director for diversity, equity and inclusion, said in a statement. “The interns selected to participate in the Rudene Mercer Haynes CTO Summer Internship will be expected live up to her standard of excellence, service and humor.”

VCU Massey Cancer Center wins $3.3M grant for lung cancer research center

The Virginia Commonwealth University Massey Cancer Center won a $3.3 million Specialized Program of Research Excellence (SPORE) grant to establish a research center on lung cancer disparities from the National Cancer Institute last week.

The Translational Research Center in Lung Cancer Disparities (TRACER) will study the disproportionate effects of lung cancer on the Black community. The center will be based at the VCU Massey Cancer Center and led by Massey, collaborating with the Medical University of South Carolina (MUSC) Hollings Cancer Center and City of Hope in California. After the three-year funding period of this initial award, the center can apply for a larger, five-year SPORE award.

TRACER will speak with local health departments, community health centers, civic activists, education institutions and others in Virginia, South Carolina and California.

“It’s important that the community has a seat at the table. We’re optimistic that this dream team of researchers and community stakeholders will translate our basic science into clinical impact in reducing lung cancer disparities,” TRACER principal investigator Dr. Robert Winn, director and Lipman Chair in Oncology at Massey and senior associate dean for cancer innovation and professor of pulmonary disease and critical care medicine at the VCU School of Medicine, said in a statement.

TRACER will investigate how stress and smoking interact with gene expression to raise lung cancer risk for Black men. Although the racial gap in lung cancer cases appears to be closing, likely due to the success of anti-smoking campaigns, Black men still have a higher risk of developing lung cancer compared to white men, even though they tend to smoke less – an effect referred to as the “Black smoking paradox,” according to an article published by the Cancer Network. Black patients are also more likely than white patients to be diagnosed at later stages and to receive no treatment at all for their cancer, according to a data analysis from the North American Association of Central Cancer Registries running from 2013 to 2017.

Winn will co-lead the project with Dr. S. Patrick Nana-Sinkam, who is a member of Massey’s Cancer Prevention and Control research program, the Linda Grandis Blatt Endowed Chair in Cancer Research and the chair of the pulmonary disease and critical care medicine division of the VCU School of Medicine.

“It’s no secret that the Black community faces higher levels of stress, compared with more socioeconomically advantaged groups,” Nana-Sinkam said in a statement. “We want to understand how environmental stress, smoking and biology intersect to increase lung cancer risk.”

The center’s second project will investigate how the stress hormone cortisol relates to racial differences in smoking behaviors and overall lung cancer risk. The project will be led by Chanita Hughes-Halbert, an adjunct at MUSC and a vice chair for research at the University of Southern California’s Keck School of Medicine and the associate director for cancer equity at the USC Norris Comprehensive Cancer Center.

VCU scientists studying cancer drug as COVID-19 treatment

A group of scientists at Virginia Commonwealth University’s Massey Cancer Center discovered that an experimental cancer drug keeps the virus that causes COVID-19 from infecting cells and replicating. Their findings were published Monday in the Biochemical Pharmacology journal and will be tested in a clinical trial at VCU Health.

AR-12 has been studied as an anti-cancer and antiviral drug in Massey researcher Paul Dent’s lab, and Dent and others have found that the oral medication is effective against Zika, mumps, measles, drug-resistant HIV and the flu, according to a news release from VCU. Laurence Booth of VCU and Jonathan O. Rayner of the University of South Alabama have studied the drug’s use in treating patients with COVID-19. They found it is “highly effective” against SARS-CoV-2, the virus that causes COVID.

Dent’s team also found that people of non-European descent, particularly those of African ancestry, make one type of protein, while people of European descent make a variant. This difference may explain why African American people are more prone to serious cases of COVID-19, although Dent cautioned that the observation is not conclusive. “It provides a biomarker that could be evaluated to help explain why some people get more severe illness than others,” he said in a statement.

“AR-12 works in a unique way,” added Dent, the chair of Massey’s Cancer Cell Signaling research program and a professor at VCU’s biochemistry and molecular biology department. “Unlike any other antiviral drug, it inhibits cellular chaperones, which are proteins that are required to maintain the right 3D shape of viral proteins. The shape of the virus is critical to its ability to infect and replicate.”

Dr. Andrew Poklepovic, a medical oncologist and medical director of Massey’s Clinical Trials Office, is leading the effort to start a clinical trial. In prior trials for other diseases, the medication was “safe and tolerable” to patients, Poklepovic said in a statement. Unlike most other COVID-19 drugs, which are given intravenously, AR-12 is taken orally and could be used for outpatient therapy, he said.

The Food and Drug Administration must give its approval to test the drug on COVID patients, and VCU is in talks with a drug company to manufacture enough of the medication for the trial. C19 Therapeutics, a group of entrepreneurs gathered by Massey’s associate director for basic research, Said Sebti, has recently licensed AR-12 from VCU to raise funds in support of clinical trial sponsorship.

“We are working to submit the required information for FDA approvals, and we are also in discussions with a local pharmaceutical company to manufacture the drug for the trial,” Sebti said in a statement. “We are hopeful that AR-12 will emerge as a treatment option for patients suffering from COVID-19, ultimately saving lives and contributing to the global pandemic solution.”

Other potential treatments for COVID-19 have gotten accelerated approval for testing on humans through the Coronavirus Treatment Acceleration Program.

 

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